The mechanism of skeletal muscle contraction is a process that relies on calcium signaling. However, the physiological role of calcium-induced calcium release (CICR) through the ryanodine receptor ...

Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without affecting depolarization-induced calcium release. The ...

New research has identified the specific biological mechanism behind the muscle dysfunction found in myotonic dystrophy type 1 (DM1) and further shows that calcium channel blockers can reverse these ...

Genetic inhibition of RyR1-mediated calcium-induced calcium release reveals its minimal role in skeletal muscle contraction and its critical contribution to malignant hyperthermia risk You are free to ...

Cancer patients often lose excessive amounts of weight. This affects up to 80% of patients and is mainly due to a decrease in muscle mass and fatty tissue. This cancer-induced cachexia (CIC) is ...

MHH scientist investigates how pro-inflammatory cytokines interfere with muscle metabolism and actively transform muscles.

Scientists discover that muscles repair themselves by moving thousands of internal nuclei, a rapid process that is key after ...