Mapping how Narcan reverses opioid overdose can provide a molecular blueprint for developing more effective drugs against overdose.

In a discovery that could guide the development of next-generation antidepressants and antipsychotic medications, researchers at the Icahn School of Medicine at Mount Sinai have developed new insights ...

Scientists have known for decades that opioids relieve pain by binding to molecular switches in the brain called mu-opioid receptors. What they didn't know—until now—was exactly what happens next.

Many breast cancer drugs block estrogen receptors inside cancer cells. Blocking the receptors early in disease progression staves off metastasis. But most patients with advanced disease eventually ...

New drugs that spur weight loss and treat diabetes have been taking the public—and the pharmaceutical industry—by storm. The latest entrant, Zepbound, recently joined Ozempic, Wegovy, Victoza and ...

In a recent review published in the journal Cell Metabolism, a group of authors explored how Glucagon-Like Peptide-1 receptor (GLP-1R) agonism shapes the neurovascular unit (NVU), potentially linking ...