Genome instability is the main risk factor in the development of tumors in humans. Understanding how, where, when and why these mutations are produced in DNA is one of the great objectives of the ...

Genomic instability is a defining hallmark of cancer, underpinning tumor initiation, evolution, and progression. Increasingly, genomic instability itself is recognized not merely as a consequence of ...

DNADX high scores predicted improved PFS, supporting genomic instability and DNA repair deficiency as biologically relevant determinants of sensitivity to deruxtecan’s topoisomerase I inhibitor ...

This article was published in Scientific American’s former blog network and reflects the views of the author, not necessarily those of Scientific American All cancers share ten underlying principles, ...

A powerful new discovery reveals that Nup98 a protein once thought to only ferry molecules through the nucleus plays a vital role in safeguarding the most vulnerable areas of DNA. By forming ...

Recently, the research team led by Prof. Junjiu Huang from Sun Yat-sen University, in collaboration with Prof. Fenghua Liu’s team at Guangdong Women and Children Hospital, published a study titled ...

Separate studies led by scientists at Dartmouth Hitchcock Medical Center (DMHC) and Queens University offer some clarity about the hidden causes of recurrent pregnancy loss. Data from both studies is ...

Powered by gene editing advances like CRISPR and base editing, cell and gene therapy (CGT) is delivering on the promise of genomic medicine. First-generation CAR T-cell therapies, for example, have ...

VectorBuilder, a global leader in gene delivery technologies and CDMO solutions, today announced MuteFree™ AAV, a ...