The EMBO Journal

Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Patients suffering from progranulin (PGRN) ...
The EMBO Journal

Mesenchymal tumor organoid models recapitulate rhabdomyosarcoma subtypes

Rhabdomyosarcomas (RMS) are mesenchyme‐derived tumors and the most common childhood soft tissue sarcomas. Treatment is intense, with a nevertheless poor prognosis for high‐risk patients. Discovery of ...
The EMBO Journal

A novel phosphocholine‐mimetic inhibits a pro‐inflammatory conformational change in C‐reactive protein

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. C‐reactive protein (CRP) is an early‐stage ...
The EMBO Journal

Molecular and cognitive signatures of ageing partially restored through synthetic delivery of IL2 to the brain

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Cognitive decline is a common pathological ...
The EMBO Journal

Dynamin 1xA interacts with Endophilin A1 via its spliced long C-terminus for ultrafast endocytosis

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Dynamin 1 mediates fission of endocytic ...
The EMBO Journal

Regulator of Calcineurin 1 helps coordinate whole‐body metabolism and thermogenesis

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Regulator of Calcineurin1 (RCAN1) suppresses ...
The EMBO Journal

The Ebola virus VP40 matrix layer undergoes endosomal disassembly essential for membrane fusion

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Ebola viruses (EBOVs) assemble into ...
The EMBO Journal

Adult neural stem cells and neurogenesis are resilient to intermittent fasting

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Intermittent fasting (IF) is a promising ...
The EMBO Journal

Androgen signaling stabilizes genomes to counteract senescence by promoting XRCC4 transcription

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Aging is accompanied by a decreased DNA repair ...
The EMBO Journal

A gene subset requires CTCF bookmarking during the fast post‐mitotic reactivation of mouse ES cells

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Mitosis leads to global downregulation of ...
The EMBO Journal

Viral M45 and necroptosis‐associated proteins form heteromeric amyloid assemblies

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The viral M45 protein forms functional amyloid ...
The EMBO Journal

A multi‐layered network model identifies Akt1 as a common modulator of neurodegeneration

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The accumulation of misfolded and aggregated ...