First-time use of AI for genetic circuit design demonstrated in a human cell line

There are hundreds of cell types in the human body, each with a specific role spelled out in their DNA. In theory, all it ...
Nature

The infection enigma: why some people die from typically harmless germs

Among the most famous demonstrations of genetic mutations driving infection outcome is severe combined immunodeficiency (SCID ...
eLife

A novel high-throughput single-cell DNA sequencing method reveals hidden genomic heterogeneity in the unicellular eukaryote Leishmania

This important study, which tackles the challenge of analyzing genome integrity and instability in unicellular pathogens by introducing a novel single-cell genomics approach, presents compelling ...

Researchers expand human genome map to 2.37 million regulatory DNA elements

A research team led by Zhiping Weng, Ph.D., and Jill Moore, Ph.D."18, at UMass Chan Medical School, has nearly tripled the ...

Compressed Data Technique Enables Pangenomics at Scale

Engineers at the University of California have developed a new data structure and compression technique that enables the field of pangenomics to handle unprecedented scales of genetic information. The ...