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BMJ Evidence-Based Medicine

BMJ Evidence-Based Medicine (BMJ EBM) publishes original evidence-based research, insights and opinions on what matters for health care. We focus on the tools, methods, and concepts that are basic and ...
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Opportunities, challenges and risks of using artificial intelligence for evidence synthesis

4 Institute of Medical Biometry and Statistics (IMBI), Medical Center – University of Freiburg, Faculty of Medicine, Freiburg, Germany 5 Eye Center, Medical Center, Faculty of Medicine, University of ...
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Thrombolysis with alteplase 3–4.5 hours after acute ischaemic stroke: trial reanalysis adjusted for baseline imbalances

Objectives Alteplase is commonly recommended for acute ischaemic stroke within 4.5 hours after stroke onset. The Third European Cooperative Acute Stroke Study (ECASS III) is the only trial reporting ...
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Evaluating the performance of maternal risk factors in predicting gestational diabetes mellitus: a systematic review and meta-analysis

Objective To systematically consolidate the most consistently applicable risk factors and assess their predictive performance for gestational diabetes mellitus (GDM) prediction. Design Systematic ...
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The Cochrane HPV vaccine review was incomplete and ignored important evidence of bias

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Environmental Lessons Learned and Applied (ELLA): a new framework for identifying, prioritising and implementing decarbonisation interventions in clinical care pathways

A multidisciplinary framework for designing rapidly deployable, scalable and context-specific decarbonisation interventions for clinical care has been developed within the National Health Service, ...
BMJ Evidence-Based Medicine

Reporting GUideline for Intervention DEscription in Rehabilitation (GUIDE-Rehab): a tool to open the ‘black box’ of rehabilitation complex interventions

In 2023, the World Health Assembly adopted a resolution to strengthen rehabilitation within health systems, calling for ...
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How good is the evidence to support primary care practice?

Correspondence to Dr Mark H Ebell, Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, 125 Miller Hall, UGA Health Sciences Campus, Athens, GA 30602, USA; ...
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Current knowledge on the adaptation of clinical practice guidelines: a scoping review

Background The adaptation of clinical practice guidelines (CPGs) is increasingly used to efficiently develop contextualised recommendations for local, regional and national settings. However, ...
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Ataluren for Duchenne: how politics and social pressure undermined evidence-based decisions

Last 28 March 2025, the European Commission decided not to renew the conditional marketing authorisation for Translarna (ataluren) in Duchenne’s disease due to lack of efficacy after 11 years in the ...
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Less is more - but for whom? Evaluating patient reported outcomes in de-implementation

All over the world, patients receive healthcare that has little to no benefit, also called low-value care. There have been an increasing number of initiatives to reduce, or de-implement, low-value ...
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Count outcomes, rate ratios and rate differences

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